Drug eluting stent implantation in patients requiring concomitant vitamin K antagonist therapy. One-year outcome of the worldwide e-SELECT registry
Identifieur interne : 005011 ( Main/Exploration ); précédent : 005010; suivant : 005012Drug eluting stent implantation in patients requiring concomitant vitamin K antagonist therapy. One-year outcome of the worldwide e-SELECT registry
Auteurs : Manel Sabate [Espagne] ; Salvatore Brugaletta [Espagne] ; Alexandre Abizaid [Brésil] ; Adrian Banning [Royaume-Uni] ; Antonio Bartorelli [Italie] ; Vladimír Dzavik [Canada] ; Stephen Ellis [États-Unis] ; David Holmes [États-Unis] ; RUNLIN GAO [République populaire de Chine] ; MYUNG HO JEONG [Corée du Sud] ; Victor Legrand [Belgique] ; Franz-Josef Neumann [Allemagne] ; Maria Nyakern [Belgique] ; Christian Spaulding [France] ; Hans-Peter Stoll [Belgique] ; Stephen Worthley [Australie] ; Philip Urban [Suisse]Source :
- International journal of cardiology [ 0167-5273 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Cardiopathie coronaire, Thrombose, Hémorragie, Pathologie de l'appareil circulatoire, Stent à élution médicamenteuse, Implantation, Homme, Malade, Vitamine K, Antagoniste, Pronostic, Evolution, Registre, Artère coronaire, Endoprothèse, Sirolimus, Immunodépresseur, Antivitamine K, Anticoagulant, Cardiologie, Traitement instrumental, Antibiotique, Anticancéreux, Antibactérien.
- Wicri :
- topic : Homme, Antibiotique.
English descriptors
- KwdEn :
- Antagonist, Antibacterial agent, Antibiotic, Anticoagulant, Antineoplastic agent, Antivitamin K, Cardiology, Cardiovascular disease, Coronary artery, Coronary heart disease, Drug eluting stent, Endoprosthesis, Evolution, Hemorrhage, Human, Immunosuppressive agent, Implantation, Instrumentation therapy, Patient, Prognosis, Register, Sirolimus, Thrombosis, Vitamin K.
Abstract
Background: Outcome of sirolimus-eluting stent (SES) in patients treated with an antivitamin K (VKA) agent before the PCI procedure is unknown. Methods: A total of 7651 patients were selected among 15,147 recipients of SES, included in the worldwide e-SELECT registry, only from those centers which included at least one patient requiring VKA: 296 were pretreated with a VKA agent (VKA group), whereas 7355 patients from the same enrolling medical centers were not (NON-VKA group). The rates of 1) major adverse cardiac events (MACE), including all-cause deaths, myocardial infarction (MI) and target lesion revascularization, 2) stent thrombosis (ST) and 3) major bleeding (MB) in the 2 study groups were compared at 1, 6 and 12 months. Results: The patients in VKA group were on average older as compared to those in NON-VKA group (67.7 ± 9.9 vs.62.9 ± 10.7, P < 0.001). The indications for pre-procedural anticoagulation were atrial fibrillation in 177 (59.8%), presence of a prosthetic valve in 21 (7.1%), embolization of cardiac origin in 17 (5.7%), pulmonary embolism or deep vein thrombosis in 17 (5.7%), and miscellaneous diagnoses in 64 (21.6%) patients. At 1 year, the rates of MACE and MB were higher in the VKA vs. the NON-VKA group (8.3% and 3% vs. 5.3% and 1.2%, P < 0.04and P < 0.002, respectively). The 1-year rates of definite and probable ST were remarkably low in both groups (0.38% vs. 1.1%, p = 0.4). Conclusions: Selected patients anticoagulated with VKA agent may safely undergo SES implantation. Those patients may receive a variety of APT regimen at the cost of a moderate increased risk of MB.
Affiliations:
- Allemagne, Australie, Belgique, Brésil, Canada, Corée du Sud, Espagne, France, Italie, Royaume-Uni, République populaire de Chine, Suisse, États-Unis
- Angleterre, Catalogne, Lombardie, Oxfordshire, Île-de-France
- Barcelone, Milan, Oxford, Paris, Pékin
Links toward previous steps (curation, corpus...)
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- to stream PascalFrancis, to step Checkpoint: 000A15
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- to stream Main, to step Curation: 005011
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Drug eluting stent implantation in patients requiring concomitant vitamin K antagonist therapy. One-year outcome of the worldwide e-SELECT registry</title><author><name sortKey="Sabate, Manel" sort="Sabate, Manel" uniqKey="Sabate M" first="Manel" last="Sabate">Manel Sabate</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hospital Clinic</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Brugaletta, Salvatore" sort="Brugaletta, Salvatore" uniqKey="Brugaletta S" first="Salvatore" last="Brugaletta">Salvatore Brugaletta</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hospital Clinic</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Abizaid, Alexandre" sort="Abizaid, Alexandre" uniqKey="Abizaid A" first="Alexandre" last="Abizaid">Alexandre Abizaid</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Instituto Dante Pazzanese de Cardiologia</s1><s2>Sao Paolo</s2><s3>BRA</s3><sZ>3 aut.</sZ></inist:fA14><country>Brésil</country><wicri:noRegion>Instituto Dante Pazzanese de Cardiologia</wicri:noRegion></affiliation></author><author><name sortKey="Banning, Adrian" sort="Banning, Adrian" uniqKey="Banning A" first="Adrian" last="Banning">Adrian Banning</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>John Radcliffe Hospital</s1><s2>Oxford</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Bartorelli, Antonio" sort="Bartorelli, Antonio" uniqKey="Bartorelli A" first="Antonio" last="Bartorelli">Antonio Bartorelli</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Centro Cardiologico Monzino, IRCCS, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Dzavik, Vladimir" sort="Dzavik, Vladimir" uniqKey="Dzavik V" first="Vladimír" last="Dzavik">Vladimír Dzavik</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Peter Munk Cardiac Centre, University Health Network</s1><s2>Toronto</s2><s3>CAN</s3><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Ellis, Stephen" sort="Ellis, Stephen" uniqKey="Ellis S" first="Stephen" last="Ellis">Stephen Ellis</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Cleveland Clinic Foundation</s1><s2>Cleveland</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cleveland Clinic Foundation</wicri:noRegion></affiliation></author><author><name sortKey="Holmes, David" sort="Holmes, David" uniqKey="Holmes D" first="David" last="Holmes">David Holmes</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Mayo Clinic</s1><s2>Rochester, MN</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Mayo Clinic</wicri:noRegion></affiliation></author><author><name sortKey="Runlin Gao" sort="Runlin Gao" uniqKey="Runlin Gao" last="Runlin Gao">RUNLIN GAO</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Cardiovascular Institute and Fu Wai Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Myung Ho Jeong" sort="Myung Ho Jeong" uniqKey="Myung Ho Jeong" last="Myung Ho Jeong">MYUNG HO JEONG</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Heart Center of Chonnam National University Hospital</s1><s2>Gwangju</s2><s3>KOR</s3><sZ>10 aut.</sZ></inist:fA14><country>Corée du Sud</country><wicri:noRegion>The Heart Center of Chonnam National University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Legrand, Victor" sort="Legrand, Victor" uniqKey="Legrand V" first="Victor" last="Legrand">Victor Legrand</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Centre Hospitalier Universitaire</s1><s2>Liège</s2><s3>BEL</s3><sZ>11 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Centre Hospitalier Universitaire</wicri:noRegion></affiliation></author><author><name sortKey="Neumann, Franz Josef" sort="Neumann, Franz Josef" uniqKey="Neumann F" first="Franz-Josef" last="Neumann">Franz-Josef Neumann</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Herz-Zentrum Bad Krozingen</s1><s2>Bad Krozingen</s2><s3>DEU</s3><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Bad Krozingen</wicri:noRegion><wicri:noRegion>Herz-Zentrum Bad Krozingen</wicri:noRegion><wicri:noRegion>Herz-Zentrum Bad Krozingen</wicri:noRegion></affiliation></author><author><name sortKey="Nyakern, Maria" sort="Nyakern, Maria" uniqKey="Nyakern M" first="Maria" last="Nyakern">Maria Nyakern</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Cordis Clinical Research Europe</s1><s2>Waterloo</s2><s3>BEL</s3><sZ>13 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Cordis Clinical Research Europe</wicri:noRegion></affiliation></author><author><name sortKey="Spaulding, Christian" sort="Spaulding, Christian" uniqKey="Spaulding C" first="Christian" last="Spaulding">Christian Spaulding</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Cardiology, Cochin Hospital, Paris Descartes University</s1><s2>Paris</s2><s3>FRA</s3><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Stoll, Hans Peter" sort="Stoll, Hans Peter" uniqKey="Stoll H" first="Hans-Peter" last="Stoll">Hans-Peter Stoll</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Cordis Clinical Research Europe</s1><s2>Waterloo</s2><s3>BEL</s3><sZ>13 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Cordis Clinical Research Europe</wicri:noRegion></affiliation></author><author><name sortKey="Worthley, Stephen" sort="Worthley, Stephen" uniqKey="Worthley S" first="Stephen" last="Worthley">Stephen Worthley</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Cardiovascular Investigation Unit, Royal Adelaide Hospital</s1><s2>Adelaide</s2><s3>AUS</s3><sZ>16 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One-year outcome of the worldwide e-SELECT registry</title><author><name sortKey="Sabate, Manel" sort="Sabate, Manel" uniqKey="Sabate M" first="Manel" last="Sabate">Manel Sabate</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hospital Clinic</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Brugaletta, Salvatore" sort="Brugaletta, Salvatore" uniqKey="Brugaletta S" first="Salvatore" last="Brugaletta">Salvatore Brugaletta</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Hospital Clinic</s1><s2>Barcelona</s2><s3>ESP</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Espagne</country><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Abizaid, Alexandre" sort="Abizaid, Alexandre" uniqKey="Abizaid A" first="Alexandre" last="Abizaid">Alexandre Abizaid</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Instituto Dante Pazzanese de Cardiologia</s1><s2>Sao Paolo</s2><s3>BRA</s3><sZ>3 aut.</sZ></inist:fA14><country>Brésil</country><wicri:noRegion>Instituto Dante Pazzanese de Cardiologia</wicri:noRegion></affiliation></author><author><name sortKey="Banning, Adrian" sort="Banning, Adrian" uniqKey="Banning A" first="Adrian" last="Banning">Adrian Banning</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>John Radcliffe Hospital</s1><s2>Oxford</s2><s3>GBR</s3><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Oxford</settlement><region type="country">Angleterre</region><region type="comté" nuts="2">Oxfordshire</region></placeName></affiliation></author><author><name sortKey="Bartorelli, Antonio" sort="Bartorelli, Antonio" uniqKey="Bartorelli A" first="Antonio" last="Bartorelli">Antonio Bartorelli</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Centro Cardiologico Monzino, IRCCS, University of Milan</s1><s2>Milan</s2><s3>ITA</s3><sZ>5 aut.</sZ></inist:fA14><country>Italie</country><placeName><settlement type="city">Milan</settlement><region nuts="2">Lombardie</region></placeName></affiliation></author><author><name sortKey="Dzavik, Vladimir" sort="Dzavik, Vladimir" uniqKey="Dzavik V" first="Vladimír" last="Dzavik">Vladimír Dzavik</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Peter Munk Cardiac Centre, University Health Network</s1><s2>Toronto</s2><s3>CAN</s3><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Ellis, Stephen" sort="Ellis, Stephen" uniqKey="Ellis S" first="Stephen" last="Ellis">Stephen Ellis</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Cleveland Clinic Foundation</s1><s2>Cleveland</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Cleveland Clinic Foundation</wicri:noRegion></affiliation></author><author><name sortKey="Holmes, David" sort="Holmes, David" uniqKey="Holmes D" first="David" last="Holmes">David Holmes</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Mayo Clinic</s1><s2>Rochester, MN</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14><country>États-Unis</country><wicri:noRegion>Mayo Clinic</wicri:noRegion></affiliation></author><author><name sortKey="Runlin Gao" sort="Runlin Gao" uniqKey="Runlin Gao" last="Runlin Gao">RUNLIN GAO</name><affiliation wicri:level="3"><inist:fA14 i1="08"><s1>Cardiovascular Institute and Fu Wai Hospital</s1><s2>Beijing</s2><s3>CHN</s3><sZ>9 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Myung Ho Jeong" sort="Myung Ho Jeong" uniqKey="Myung Ho Jeong" last="Myung Ho Jeong">MYUNG HO JEONG</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>The Heart Center of Chonnam National University Hospital</s1><s2>Gwangju</s2><s3>KOR</s3><sZ>10 aut.</sZ></inist:fA14><country>Corée du Sud</country><wicri:noRegion>The Heart Center of Chonnam National University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Legrand, Victor" sort="Legrand, Victor" uniqKey="Legrand V" first="Victor" last="Legrand">Victor Legrand</name><affiliation wicri:level="1"><inist:fA14 i1="10"><s1>Centre Hospitalier Universitaire</s1><s2>Liège</s2><s3>BEL</s3><sZ>11 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Centre Hospitalier Universitaire</wicri:noRegion></affiliation></author><author><name sortKey="Neumann, Franz Josef" sort="Neumann, Franz Josef" uniqKey="Neumann F" first="Franz-Josef" last="Neumann">Franz-Josef Neumann</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Herz-Zentrum Bad Krozingen</s1><s2>Bad Krozingen</s2><s3>DEU</s3><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Bad Krozingen</wicri:noRegion><wicri:noRegion>Herz-Zentrum Bad Krozingen</wicri:noRegion><wicri:noRegion>Herz-Zentrum Bad Krozingen</wicri:noRegion></affiliation></author><author><name sortKey="Nyakern, Maria" sort="Nyakern, Maria" uniqKey="Nyakern M" first="Maria" last="Nyakern">Maria Nyakern</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Cordis Clinical Research Europe</s1><s2>Waterloo</s2><s3>BEL</s3><sZ>13 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Cordis Clinical Research Europe</wicri:noRegion></affiliation></author><author><name sortKey="Spaulding, Christian" sort="Spaulding, Christian" uniqKey="Spaulding C" first="Christian" last="Spaulding">Christian Spaulding</name><affiliation wicri:level="3"><inist:fA14 i1="13"><s1>Department of Cardiology, Cochin Hospital, Paris Descartes University</s1><s2>Paris</s2><s3>FRA</s3><sZ>14 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Stoll, Hans Peter" sort="Stoll, Hans Peter" uniqKey="Stoll H" first="Hans-Peter" last="Stoll">Hans-Peter Stoll</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Cordis Clinical Research Europe</s1><s2>Waterloo</s2><s3>BEL</s3><sZ>13 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Cordis Clinical Research Europe</wicri:noRegion></affiliation></author><author><name sortKey="Worthley, Stephen" sort="Worthley, Stephen" uniqKey="Worthley S" first="Stephen" last="Worthley">Stephen Worthley</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Cardiovascular Investigation Unit, Royal Adelaide Hospital</s1><s2>Adelaide</s2><s3>AUS</s3><sZ>16 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Urban, Philip" sort="Urban, Philip" uniqKey="Urban P" first="Philip" last="Urban">Philip Urban</name><affiliation wicri:level="1"><inist:fA14 i1="15"><s1>La Tour Hospital</s1><s2>Geneva</s2><s3>CHE</s3><sZ>17 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>La Tour Hospital</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">International journal of cardiology</title><title level="j" type="abbreviated">Int. j. cardiol.</title><idno type="ISSN">0167-5273</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">International journal of cardiology</title><title level="j" type="abbreviated">Int. j. cardiol.</title><idno type="ISSN">0167-5273</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antagonist</term><term>Antibacterial agent</term><term>Antibiotic</term><term>Anticoagulant</term><term>Antineoplastic agent</term><term>Antivitamin K</term><term>Cardiology</term><term>Cardiovascular disease</term><term>Coronary artery</term><term>Coronary heart disease</term><term>Drug eluting stent</term><term>Endoprosthesis</term><term>Evolution</term><term>Hemorrhage</term><term>Human</term><term>Immunosuppressive agent</term><term>Implantation</term><term>Instrumentation therapy</term><term>Patient</term><term>Prognosis</term><term>Register</term><term>Sirolimus</term><term>Thrombosis</term><term>Vitamin K</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Cardiopathie coronaire</term><term>Thrombose</term><term>Hémorragie</term><term>Pathologie de l'appareil circulatoire</term><term>Stent à élution médicamenteuse</term><term>Implantation</term><term>Homme</term><term>Malade</term><term>Vitamine K</term><term>Antagoniste</term><term>Pronostic</term><term>Evolution</term><term>Registre</term><term>Artère coronaire</term><term>Endoprothèse</term><term>Sirolimus</term><term>Immunodépresseur</term><term>Antivitamine K</term><term>Anticoagulant</term><term>Cardiologie</term><term>Traitement instrumental</term><term>Antibiotique</term><term>Anticancéreux</term><term>Antibactérien</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Antibiotique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Outcome of sirolimus-eluting stent (SES) in patients treated with an antivitamin K (VKA) agent before the PCI procedure is unknown. Methods: A total of 7651 patients were selected among 15,147 recipients of SES, included in the worldwide e-SELECT registry, only from those centers which included at least one patient requiring VKA: 296 were pretreated with a VKA agent (VKA group), whereas 7355 patients from the same enrolling medical centers were not (NON-VKA group). The rates of 1) major adverse cardiac events (MACE), including all-cause deaths, myocardial infarction (MI) and target lesion revascularization, 2) stent thrombosis (ST) and 3) major bleeding (MB) in the 2 study groups were compared at 1, 6 and 12 months. Results: The patients in VKA group were on average older as compared to those in NON-VKA group (67.7 ± 9.9 vs.62.9 ± 10.7, P < 0.001). The indications for pre-procedural anticoagulation were atrial fibrillation in 177 (59.8%), presence of a prosthetic valve in 21 (7.1%), embolization of cardiac origin in 17 (5.7%), pulmonary embolism or deep vein thrombosis in 17 (5.7%), and miscellaneous diagnoses in 64 (21.6%) patients. At 1 year, the rates of MACE and MB were higher in the VKA vs. the NON-VKA group (8.3% and 3% vs. 5.3% and 1.2%, P < 0.04and P < 0.002, respectively). The 1-year rates of definite and probable ST were remarkably low in both groups (0.38% vs. 1.1%, p = 0.4). Conclusions: Selected patients anticoagulated with VKA agent may safely undergo SES implantation. Those patients may receive a variety of APT regimen at the cost of a moderate increased risk of MB.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Brésil</li><li>Canada</li><li>Corée du Sud</li><li>Espagne</li><li>France</li><li>Italie</li><li>Royaume-Uni</li><li>République populaire de Chine</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Catalogne</li><li>Lombardie</li><li>Oxfordshire</li><li>Île-de-France</li></region><settlement><li>Barcelone</li><li>Milan</li><li>Oxford</li><li>Paris</li><li>Pékin</li></settlement></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Sabate, Manel" sort="Sabate, Manel" uniqKey="Sabate M" first="Manel" last="Sabate">Manel Sabate</name></region><name sortKey="Brugaletta, Salvatore" sort="Brugaletta, Salvatore" uniqKey="Brugaletta S" first="Salvatore" last="Brugaletta">Salvatore Brugaletta</name></country><country name="Brésil"><noRegion><name sortKey="Abizaid, Alexandre" sort="Abizaid, Alexandre" uniqKey="Abizaid A" first="Alexandre" last="Abizaid">Alexandre Abizaid</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Banning, Adrian" sort="Banning, Adrian" uniqKey="Banning A" first="Adrian" last="Banning">Adrian Banning</name></region></country><country name="Italie"><region name="Lombardie"><name sortKey="Bartorelli, Antonio" sort="Bartorelli, Antonio" uniqKey="Bartorelli A" first="Antonio" last="Bartorelli">Antonio Bartorelli</name></region></country><country name="Canada"><noRegion><name sortKey="Dzavik, Vladimir" sort="Dzavik, Vladimir" uniqKey="Dzavik V" first="Vladimír" last="Dzavik">Vladimír Dzavik</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Ellis, Stephen" sort="Ellis, Stephen" uniqKey="Ellis S" first="Stephen" last="Ellis">Stephen Ellis</name></noRegion><name sortKey="Holmes, David" sort="Holmes, David" uniqKey="Holmes D" first="David" last="Holmes">David Holmes</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Runlin Gao" sort="Runlin Gao" uniqKey="Runlin Gao" last="Runlin Gao">RUNLIN GAO</name></noRegion></country><country name="Corée du Sud"><noRegion><name sortKey="Myung Ho Jeong" sort="Myung Ho Jeong" uniqKey="Myung Ho Jeong" last="Myung Ho Jeong">MYUNG HO JEONG</name></noRegion></country><country name="Belgique"><noRegion><name sortKey="Legrand, Victor" sort="Legrand, Victor" uniqKey="Legrand V" first="Victor" last="Legrand">Victor Legrand</name></noRegion><name sortKey="Nyakern, Maria" sort="Nyakern, Maria" uniqKey="Nyakern M" first="Maria" last="Nyakern">Maria Nyakern</name><name sortKey="Stoll, Hans Peter" sort="Stoll, Hans Peter" uniqKey="Stoll H" first="Hans-Peter" last="Stoll">Hans-Peter Stoll</name></country><country name="Allemagne"><noRegion><name sortKey="Neumann, Franz Josef" sort="Neumann, Franz Josef" uniqKey="Neumann F" first="Franz-Josef" last="Neumann">Franz-Josef Neumann</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Spaulding, Christian" sort="Spaulding, Christian" uniqKey="Spaulding C" first="Christian" last="Spaulding">Christian Spaulding</name></region></country><country name="Australie"><noRegion><name sortKey="Worthley, Stephen" sort="Worthley, Stephen" uniqKey="Worthley S" first="Stephen" last="Worthley">Stephen Worthley</name></noRegion></country><country name="Suisse"><noRegion><name sortKey="Urban, Philip" sort="Urban, Philip" uniqKey="Urban P" first="Philip" last="Urban">Philip Urban</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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